Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

AA Harutyunyan

doi:10.61927/igmin113

2 of 183

Lhamu Sherpa and Nandan Banerji

4 of 183

The Antioxidant and Antidepressant Properties of Dietary Proteins Derived from Egg and Bean Extracts and Their Acute Toxicity: A Journey from Nutrition to Pharmacognosy

Amal El Hamsas El Youbi, Omaima Boudaia, Zineb Sekkout, Najat El Amrani and Driss Radallah

Biology Group Research Article Article ID: igmin113

Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

Biochemistry DOI10.61927/igmin113

AA Harutyunyan ^*

Affiliation

AA Harutyunyan, The Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA 26, Azatutyan Ave., Yerevan, 0014, Armenia, Email: harutyunyan.arthur@yahoo.com

Fulltext HTML Fulltext PDF Cite this article

21

REFERENCES

2.7k

VIEWS

902

DOWNLOADS

105

Abstract

Synthetic approaches to the construction of the heterocyclic benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidine system based on heterocyclizations of substituted benzimidazoles and a new alternative strategy based on 2,4,6-trisubstituted pyrimidinyl-5-propanoic acids are considered. The latter method has been shown to be a successful addition to previously described methods, since it allows one to bypass the significant limitations associated with the use of substituted benzimidazoles and allows the introduction of functional substituents at different positions of the heterocycle that are inaccessible by other methods. The available information on derivatives of this heterocyclic system and their biological properties is summarized.

Figures

References

Jampilek J. Heterocycles in Medicinal Chemistry. Molecules. 2019 Oct 25;24(21):3839. doi: 10.3390/molecules24213839. PMID: 31731387; PMCID: PMC6864827.
Sharma PK, Amin A, Kumar M. A Review: Medicinally important nitrogen sulphur containing heterocycles. Open Med. Chem. J. 2020; 14:49-64.org/10.2174/1874104502014010049
Kabir E, Uzzaman M. A review on biological and medicinal impact of heterocyclic compounds. Results in Chemistry. 2022; 4:100606. doi.org/10.1016/j.rechem.2022.100606
Sharma V, Gupta M, Kumar P, Sharma A. A Comprehensive Review on Fused Heterocyclic as DNA Intercalators: Promising Anticancer Agents. Curr Pharm Des. 2021;27(1):15-42. doi: 10.2174/1381612826666201118113311. PMID: 33213325.
Jubete G, de la Bellacasa PR, Estrada-Tejedor R, Teixido J, Borrell JI. Pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis and biomedical applications. Molecules. 2019; 24:4161. doi.org/10.3390/molecules24224161
Tahlan S, Kumar S, Narasimhan B. Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review. BMC Chem. 2019 Aug 6;13(1):101. doi: 10.1186/s13065-019-0625-4. PMID: 31410412; PMCID: PMC6685272.
Xiong H, Yu Q, Ma H, Yu X, Ouyang Y, Zhang ZM, Zhou W, Zhang Z, Cai Q. Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors. RSC Med Chem. 2023 Jul 21;14(10):2007-2011. doi: 10.1039/d3md00209h. PMID: 37859717; PMCID: PMC10583808.
CA Chem. Substance Index. v.95, 6179CS. 1981.
Hunter AD. ACD/ChemSketch 1.0 (freeware); ACD/ChemSketch 2.0 and its tautomers,dictionary, and 3D plug-ins; ACD/HNMR 2.0; ACD/CNMR 2.0. Chem. Educ. Easton.1997;74(8):905-908.
Pyrimido[5’,4’:5,6]pyrido[1,2-a] Ger. Offen. Chem. Abstr. 1981; 95: P44732; 2.929. 414.
Electrophotographic recording material. Wiedemann W. (Hoechst A.-G.). Ger. Offen. DE3.502.689, 33 pp. Chem. Abstr. 1987; 106:41561j.
Electrophotographic recording material. Wiedemann W, Guenther D. (Hoechst A.-G.). Ger.Offen. Chem. Abstr. 1988; 108: DE 3.502.681;28:122003x.
Bogdanowicz-Szwed K, Czarny A. Synthesis of polyazaheterocycles by Michael addition of CH acids to a α,β-unsaturated nitriles. Synthesis of pyrido[1,2-a]benzimidazole and pyrimido[5′,4' : 5,6]pyrido[l,2-a]benzimidazole derivatives. J. prakt. Chem. 1993; 335:279. org/10.1002/prac.19933350311
Elwan NM. First synthesis of novel pentaheterocyclic ring system of 1,2,4-triazolo[2",3":6',1']pyrimido[4',5':2,3]pyrido[1,2-a] J. Heterocyclic Chem. 2004; 41:281. doi.org/10.1002/jhet.5570410222
El-Zohry MF, Mohamed TA, Hussein EM. Novel syntheses of some new 3,4- dihydrospiro{benzimidazo[1,2-a]pyridine-3,30-indolin}-20-one derivatives. Monatsh. Chem. 2009; 140:265. org/10.1007/s00706-008-0013-6
Harutyunyan AA. Synthesis of the derivatives of the new heterocyclic system 5,6-dihydrobenzo[4',5']imidazo[2',1':6,1]pyrido[2,3-d] Chem. J. Armenia. 2012; 65(2):257. https://arar.sci.am/publication/204311
Harutyunyan АA, Panosyan HA, Tamazyan RA, Ayvazyan AG. New derivatives of the benzo[4,5]imidazo[2',1':6,1]pyrido[2,3-d] Chem. J. Armenia. 2016; 69(3):266. https://arar.sci.am/publication/205621
Harutyunyan AA. Studies in the field of the pyrimidines and polycyclic azaheterocycles synthesis. The dissertation abstract of the doctor of chemical sciences. Armenia, Yerevan. 2017.
Harutyunyan AA. Syntheses and biological properties of benzo[4', 5']imidazo[2',1': 6,1]-pyrido[2,3-d]pyrimidines: mini-review. Chem. J. Armenia. 2018; 71(4):579. https://arar.sci.am/publication/206351
Harutyunyan AA, Gukasyan GT, Panosyan HA, Tamazyan RA, Ayvazyan AG, Grigoryan AG, Danagulyan GG. Synthesis of new derivatives of benzo[4',5']imidazo[2 ',1': 6,1]pyrido[2,3-d] Russ. J. Org. Chem. 2019; 55(11):1698. doi.org/10.1134/S1070428019110095
Harutyunyan AA, Israelyan SG, Safaryan MS, Hakobyan MR, Sumbatyan AS, Dilanyan SV. Synthesis and biological properties of derivatives of five- and six-membered azaheterocycles and their condensed systems. Brief review of research by the laboratory for the synthesis of anti-cancer compounds in 2019-2023. Some Successes Organic and Pharmaceutical Chemistry. Collection of works. Issue 4, p. 112-135 (in English). Armenia, Yerevan. 2023; ISBN 978-9939-1-1712-6.

Similar Articles

Utilising Phytoremediation in Green Technologies: Exploring Natural Means of Environmental Clean-up
LM KalimoldinaAskarova Shinar Kuanganovna, Zhaksybayeva Gulzhan Satzhankyzy, Zh.E. Shaikhova and Sultangaziy Eva Gulbaram Sapina
DOI10.61927/igmin276

Examining the Causal Connection between Lipid-lowering Medications and Malignant Meningiomas through Drug-target Mendelian Randomization Analysis
Liantai Song, Xiaoyan Guo, Wenhui Zhang, Mengjie Li, Xinyi Wu, Ziqian Kou, Yuxin Wang, Zigeng Ren and Qian Xu
DOI10.61927/igmin187

AI-Driven Smart Auditory Health Systems: Bridging Audiology and Public Health in Low- and Middle-Income Countries
MD Nahid Hassan Nishan, Anika Ferdous and Farhana Jahan
DOI10.61927/igmin272

A Study to Determine the Reason for Lower Pregnancy Rates in Younger Women with Diminished Oocyte Reserve-less Chance of Implanting vs. Fetal Demise
Jerome H Check, Brooke Neumann, Diane L Check and Michael Sobel
DOI10.61927/igmin188

Modeling of an Electric-fired Brick Oven, Directly Heated
André-Jacques Nlandu Mvuezolo, Jean Noël Luzolo Ngimbi and Lucien Mbozi
DOI10.61927/igmin157

Tone Alternation, Polarity, and Down-stepping Influences in Four Noun Categories in Lama
Yanting Sun
DOI10.61927/igmin273

Boundary Value Problems in Ellipsoidal Geometry and Applications
Panayiotis Vafeas
DOI10.61927/igmin263

Biomimetic Synthesis of Calcium Carbonate in Bile in the presence of Amino Acids
Olga Golovanova
DOI10.61927/igmin227

Gaussian-Transform for the Dirac Wave Function and its Application to the Multicenter Molecular Integral Over Dirac Wave Functions for Solving the Molecular Matrix Dirac Equation
Kazuhiro Ishida
DOI10.61927/igmin266

Efficacy of Alternative Insecticides against Dusky Cotton Bug (Oxycarenus laetus) to Improve Yield Losses in Cotton Crops through Residue-based Bioassay
Muhammad Salman Hameed, Muhammad Arshad, Khurshied Ahmed Khan and Nida Urooj
DOI10.61927/igmin249

Page Navigation

PUBLISH YOUR RESEARCH

We publish a wide range of article types in biology, medicine and engineering with no editorial biases.

Submit

See Manuscript Guidelines and APC

Explore the IgMin Subjects

Click for top 10 Articles

Quick Links

Submit Manuscript

Browse by Subjects

Members

Articles

Explore Content

Identify Us

Publish Now

Policies

Manuscript Guidelines

Other Services

Identify Us

Search

Select Language

Explore Section